The Rodent Uterotrophic Assay: Critical Protocol Features, Studies with Nonyl Phenols, and Comparison with a Yeast Estrogenicity Assay
نویسندگان
چکیده
منابع مشابه
THE RODENT UTEROTROPHIC ASSAY : CRITICAL PROTOCOL FEATURES, STUDIES WITH NONYLPHENOLS, COMPARISON WITH A YEAST ESTROGENICITY ASSAY by
2 SUMMARY The major protocol features of the immature rat uterotrophic assay have been evaluated using a range of reference chemicals. The protocol variables considered include the selection of the test species and route of chemical administration, the age of the test animals, the maintenance diet used and the specificity of the assay for estrogens. It is concluded that three daily oral DGPLQLV...
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چکیده ندارد.
The mouse uterotrophic assay: a reevaluation of its validity in assessing the estrogenicity of bisphenol A.
The prevalence of synthetic chemicals in our environment that are capable of mimicking the female hormone estrogen is a growing concern. One such chemical, bisphenol A (BPA), has been shown to leach from a variety of resin-based and plastic products, including dental sealants and food and beverage containers, in concentrations that are sufficient to induce cell proliferation in vitro. The respo...
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15 صفحه اولIncreasing the sensitivity of the rodent uterotrophic assay to estrogens, with particular reference to bisphenol A.
The gravimetric uterotrophic assay is currently the most well-established, short-term rodent estrogenicity assay. Increasing attention is being paid to the extent to which use of morphometric or molecular changes in the uterus could act as surrogates for the gravimetric end point of the assay, thereby perhaps increasing the sensitivity of the assay. In this paper I discuss the available data, p...
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ژورنال
عنوان ژورنال: Regulatory Toxicology and Pharmacology
سال: 1997
ISSN: 0273-2300
DOI: 10.1006/rtph.1997.1100